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KMID : 0438219790160020347
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Korea University Medical Journal
1979 Volume.16 No. 2 p.347 ~ p.355
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The Influence of Urokinase on the Absorption of Simulated Anterior Chamber Hemorrhages in Rabbits
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Abstract
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A total hyphema is frequently experienced in ocular disease as a complication which results from the trauma of intraocular surgery. Clinically it is very important because of its serious complications such as secondary glaucoma, corneal blood stain, cataract formation, and phthisis bulbi.
Recently, the author has been interested in several reports about urokinase, a fibrinolytic enzyme which has good influence on the absorption of the anterior chamber hemorrhages without any ocular complications.
In this study, simulated anterior chamber hemorrahages were induced by intracameral injection of 0.2 cc human "Cr tagged blood through the limbus at the 12 o´clock position in 28 rabbit eyes.
Thereafter, the author treated the rabbits with urokinase by subconjunctival (40 I. U. 10.3cc. intracameral (12 1. U. 10. lcc), and intravenous injections (60 I. U. /kg) everyday for 10 days.
All experimental groups were observed for the rates of the change of radioactivity of the eyes with a scintillation counter every 6 hours for one day and thereafter everyday for 9 days and results were obtained and recorded.
Final results of recorded data were summarized as follows:
1) The time required for 507o of the injected radioactivity to disappear after experimental hyphema was the 18th hour in the urkinase intracameral injection group, within 24 hours in the urokinase subconjunctival injection group, and within three days in both control and the urokinase intravenous injecton groups.
2) The urokinase subconjunctival injection group had a more rapid absorption rate than the intrac -ameral injection group in 5070 of the cases, however, in the subconjunctival injection group hemorrhage was cleared faster than the intracameral injection group after the third day of the experiment.
3) In general, control and intravenous injection groups had the slowest rate of absorption of blood from the anterior chamber. as compared to the subconjunctival and intracameral injection groups.
4) From the results, it was concluded that the urokinase subconjuntival injectioh for the hyphema was the best method considering- its effectiveness on the absorption of anterior chamber hemorrhages, its ocular complications, and its ease of application.
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